Named for Rear Admiral Edward Simpson, a Civil War-era naval hero, the USS Simpson (DD-221) was commissioned on 3 November 1920. From June 1922 through February 1924, the Simpson served with a unit of the U.S. Naval Detachment off Turkey during post-World War I unrest. In 1925, the Simpson joined the Asiatic Fleet and trained at Tsingtao and Chefoo, China. That same year, she was part of a fleet of destroyers dispatched to supplement the Yangtze gunboat patrols. She returned to the United States in April 1932 and underwent an overhaul at Mare Island. On 7 May 1934, the Simpson and the cruiser USS Milwaukee (CL-5) collided during night training exercises off Guantanamo Bay; the Simpson underwent repairs in Philadelphia.